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Botox®  vs. Xeomin®: Choosing the Right Neurotoxin to Combat Wrinkles

By FoRM Health | January 29, 2025

At FoRM Health in Portland, Oregon, we specialize in helping you look and feel your best—which may include rewinding back the clock on wrinkles using neurotoxin injections. If you’re considering injections to smooth those unwanted signs of aging, you’ve likely come across two popular options: Botox® and Xeomin®. While both yield wonderful results, they have some key differences that may influence which one is right for you. Let’s break it down.

What Do Botox™ and Xeomin™ Have in Common?

Both Botox® and Xeomin® are FDA-approved neurotoxins (derived from botulinum toxin) for the treatment of wrinkles of the forehead, frown lines (also known as “11” lines), and crow’s feet around the eyes. They work by temporarily relaxing the muscles that cause the dynamic wrinkle (wrinkle caused by movement). The result? Smoother, more youthful-looking skin. Both treatments are quick, minimally invasive, and require no downtime.

3 Key Differences Between Botox® and Xeomin®

Purity of Formulation

    • Botox®: Botox contains additional accessory proteins alongside the active ingredient, botulinum toxin. While these proteins are generally considered innocuous, they theoretically could trigger an immune response resulting in antibody formation against the proteins, potentially reducing its effectiveness over time.
    • Xeomin®: Known as a “naked” neurotoxin, Xeomin® is free of added proteins, containing only the active ingredient. This pure formulation may reduce the risk of developing antibody resistance, making it a great choice for long-term use.

 

Stronger vs. Lighter Effect:

    • Botox®: With the additional proteins, Botox® has a greater molecular weight than Xeomin®, resulting in Botox™ having a more precise and “heavier” effect in the treated area. This feature makes it the better option for individuals with strong facial expressions or those seeking minimal to no facial movement within the treated area. 
    • Xeomin®: Without the accessory proteins, Xeomin™ has a more diffuse distribution within the treated area, resulting in a “lighter” land. This “lighter” effect is thought to create a more “natural” look, allowing for some muscle movement while turning down the wrinkle formation.

 

Onset + Duration of Results:

    • Botox®: With a slightly stronger effect, results are typically first noticed 3-5 days after treatment, though the full effect may take up to 2 weeks to settle in. On average, the results from one Botox® treatment lasts about 3 months.
    • Xeomin®: The lighter quality of Xeomin® may take a few more days to settle in, typically showing up 5-7 days after treatment, with the full expression of results showing up at 2 weeks, just like Botox®. Xeomin®, however, has been reported to last longer for some patients, averaging 3.5 month duration of results. The difference in duration of effect may be attributed to the accessory proteins.

Which One Is Right for You?

The best neurotoxin for you depends on your individual needs, lifestyle, and goals. Some patients prefer Xeomin® for its pure formulation and more natural aesthetic, while others stick with Botox® for its consistent and sometimes stronger results. During your consultation at FoRM Health, Dr. Kai will discuss your aesthetic goals and help you choose the option that’s best suited for you!

Why Choose FoRM Health for Your Neurotoxin Treatments?

At FoRM Health, we combine aesthetic expertise with a holistic approach to wellness. Our goal is not just to reduce wrinkles but to enhance your natural beauty and skin health. Whether you’re new to neurotoxin treatments or looking to switch things up, you can trust us to deliver personalized care with a natural aesthetic.

Ready to smooth away wrinkles and embrace a more youthful look? Schedule your consultation at FoRM Health in Portland today!

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Aging is an honor! Yes, but there are some unwante Aging is an honor! Yes, but there are some unwanted side effects!
How is aging showing up on you?

Wrinkles? Texture changes and fine lines? Discolored complexion? Or volume loss? Let’s change that!

Our Look Better Memberships utilize powerful, evidenced-based techniques including light and energy therapies, microneedling and regenerative aesthetic procedures like Platelet Rich Fibrin (PRF) Skin Rejuvenation.

We have 3 Membership Tiers to choose from:

🌟 Glow Up – Perfect for those with early signs of aging and texture changes. 

- Primary service included: 1 Hour Custom Combo 

💆 Skin Rehab – Includes targeted treatments to repair + restore skin barrier function, address inflammation + correct discoloration.

- Primary Service included: Intermittent Pulse Light (IPL) Photorejuvenation or Microneedling (depending on skin-type)

⏳ Age Defy – Includes advanced aesthetic therapies to boost collagen, smooth fine lines, and restore volume loss.

- Primary Service included: PRF Skin Rejuvenation

Aging is an honor - and we believe in helping you age your way!

Our Aesthetician, O’Brien, and Aesthetic specialist, Dr. Kai will design a plan tailored to your goals, then watch your skin evolve month after month.

Use link in bio to learn more about Look Better Memberships + schedule your consultation with our aesthetician.

#formhealth #formhealthpdx #TopForm #sellwoodmoreland #naturalaesthetics #healthyisbeautiful #agedefy #Skinrehab #glowup #SkinRejuvenation #PRFskinrejuvenation #naturalbeauty #microneedling #ipl #iplfacial #photorejuvenation #botox #biotherapeutic #advancedaesthetician #skinbetterscience #epionce #dermaplaning #microcurrent #hydrodermabrasion #nofilterneeded
Love the way you age 💪✨ At FoRM, we combine Love the way you age 💪✨

At FoRM, we combine Functional + Regenerative Medicine to help you look, move, and feel your best at every stage of life.

💉 Regenerative Aesthetics: PRF, Microneedling, Light Therapy + more
🦵 Regenerative Orthopedics: PRP, MFAT, Prolotherapy
⚖️ Functional Medicine: Root-cause care with a focus on hormonal health

Longevity should feel + look good!

#regenerativemedicine #functionalmedicine #aestheticmedicine #hormonetherapy #bhrt #prp #prf #prolotherapy #mfat #skinrehab #glowup #menopausehelp #lookbetterfeelbetter #agedefy #formhealth
The FoRM team is all about getting you back to fee The FoRM team is all about getting you back to feeling 💯 & continuing to feel 💯 at any age! Dry-needling is amazing for targeting tight muscles + trigger points to reduce pain, improve mobility, & speed up healing so you can do what you love for as long you want. We’re so fortunate to have Sharon’s skill + expertise — she’s helping so many patients feel strong & live pain-free at every age! 💪 ✨ 

#dryneedle #movebetter #feelbetter #agingstrong #mobility #functionalmedicine #formhealthpdx #portlandacupuncture
Dr. Ryan introduces Dr. Brittany Krake, ND — the Dr. Ryan introduces Dr. Brittany Krake, ND — the newest member of our Regenerative Orthopedics team- to Regenerative Medicine, the FoRM way!

Here she joins Dr. Ryan, FoRM’s Director of Regenerative Orthopedics, for a hands-on look at our Platelet-Rich Plasma (PRP) process 🩸.

While Dr. Brittany is a already an experienced injector, our providers like to collaborate on best practices and techniques, to ensure patients get a seamless experience + most effective treatment.

Dr. Brittany observed Dr. Ryan prepare + perform a PRP injection on a painful thumb joint — helping restore mobility and reduce chronic discomfort. 💪✨

At FoRM, our Regenerative Orthopedic team uses advanced therapies including:
🧬 Micro-Fragmented Adipose Tissue (MFAT)
💉 Platelet-Rich Plasma (PRP)
🌿 Prolotherapy + Prolozone

These evidence-informed treatments help patients recover from injury, reduce arthritis pain, and improve joint function — without surgery.

#FoRMHealth #RegenerativeMedicine #PRP #OrthopedicMedicine #NaturopathicMedicine #MFAT #Prolotherapy #Prolozone #JointHealth #PainRelief #sellwoodmoreland #sellwood
Welcome Fall 🍁🍂— finally…back to cozy ro Welcome Fall 🍁🍂— finally…back to cozy routines, cooler mornings, and a chance to properly decompress ☕️📖

As we embrace the beginning of Fall, we wanted to give Summer a proper send off with photo dump of seasonal highlights 📸.

Our FoRM providers packed this season full: social get-togethers, golf (and yes, more golf), lake days + beach bonfires, long nights + bike rides, family trips + touring, outdoor concerts + sporting events — and some good trouble in Vegas runs. We came back sun-kissed, tired in the best way, and smarter for the pause.

Bring on the cooler mornings, steady rhythms, and the work we love. If your reset requires a little professional help, we’ve got you. #FoRMHealth #FallReset 
#formhealth #formhealthpdx #functionalmedicine #regenerativemedicine #naturopathicmedicine #naturopathicdoctor #feelbettermovebetterlookbetter #TopForm #sellwoodmoreland #portlandoregonclinic #integrativemedicine #feelbetter #movebetter #lookbetter
✨ Physical Therapy, the FoRM way ✨
 At FoRM ✨ Physical Therapy, the FoRM way ✨

At FoRM Health, PT isn’t just a list of prescribed exercises.
Our highly-experienced Physical Therapist, Dr. Joanne Siegel DPT, has a very “hands-on” practice!

She starts with a comprehensive, hands-on re-evaluation—spending a full 60 min with every new and return patient to uncover what’s really going on.

Every PT session includes hands-on manual therapy to address dysfunction, reduce pain, and restore mobility before even talking exercises.

Only then does she create a custom movement plan that’s strategic, sustainable, and specific to you.

📍This is PT designed to actually get you better.

#FoRMHealth #PhysicalTherapy #SportsMedicine #ManualTherapy #InjuryRecovery #MoveBetter #RegenerativeMedicine #HolisticHealth #PortlandHealthcare #sellwoodmoreland
We’re *shocked* at how well these acoustic waves We’re *shocked* at how well these acoustic waves work! 😉 

🔊 🔊 🔊 

Shockwave therapy is a non-invasive treatment that uses sound waves to stimulate healing in damaged tissues, reduce pain, + improve mobility. By promoting blood flow, reducing scarring, & accelerating tissue repair, Shockwave therapy supports the body’s natural healing processes, helping you recover faster with minimal downtime! 

Ideal for any tendinopathy (tendinitis, tendinosis, calcifications), plantar fasciitis, general pain associated with fascial adhesions/scarring, + nerve pain.

@drbinshaieg used shockwave therapy & took our nutritionist’s tennis elbow from a 5 to 1 pain level in ONE treatment. 🙌 

Want to learn more? 
🔗 in bio
📞 503 232 5653

#movebetter #shockwavetherapy #formhealthpdx #sportsmedicine #feelbetter #regenerativemedicine #orthopedicsportland #functionalmedicine
Meet Dr. Brittany Krake, ND 🌿 Regenerative Med Meet Dr. Brittany Krake, ND 🌿

Regenerative Medicine + Functional Hormone Specialist @formhealthpdx 

We’re thrilled to welcome Dr. Brittany Krake ND to the FoRM family!👏🏽
⁠
Dr. Brittany is a licensed Naturopathic Doctor with advanced training in Regenerative Orthopedic Medicine—including ultrasound-guided Platelet-Rich Plasma (PRP) injections—to help patients recover from chronic pain and acute injuries.
She also specializes in Functional Medicine and hormone health, guiding patients through every stage of hormonal change—from reproductive health and perimenopause to menopause and andropause—helping them regain balance, energy, and resilience.

Her whole-person approach blends cutting-edge regenerative therapies, hormone optimization, and lifestyle medicine to support healing, recovery, and long-term vitality.

We’re so excited to have her expertise here at FoRM to help our patients move, feel, and live better 💪✨

📍 Now accepting new patients
📌 Insurance credentialing expected Fall 2025

#FoRMHealth #RegenerativeMedicine #PRP #OrthopedicMedicine #FunctionalMedicine #HormoneHealth #WomensHealth #MensHealth #SportsMedicine #InjuryRecovery #PRPinjections #Prolotherapy #ChronicPainRelief #MoveBetter #IntegrativeMedicine #NaturopathicMedicine #PacificNorthwestHealth #PRPforInjuries #HormoneOptimization #FeelBetterLiveBetter
Summer Fun, Meet Fall Recovery 🏃‍♀️💪 Summer Fun, Meet Fall Recovery 🏃‍♀️💪

Time to focus on recovery! FoRM's Rehab program includes #prp #mfat #shockwave #sportchiropractic #physicaltherapy #dryneedling 

Schedule with one of our Naturopathic Doctors who specialize in Sports Medicine for a thorough exam and customized rehabilitation plan!
📣 TESTIMONIAL 📣 Whether you’re recovering 📣 TESTIMONIAL 📣

Whether you’re recovering from an injury, managing chronic pain, or looking to improve your movement, our Doctor of Physical Therapy, Joanne Siegel, combines her decades-long expertise with a focus on long-term wellness!

💪 Personalized rehab plans
💪 A whole-body approach to healing
💪 Functional movement and injury prevention

We love hearing these glowing reviews from Dr. Siegel’s patients. Reach out to us to learn more about her practice and start your personalized Rehab plan! 

📞 503-232-5653
🔗 in bio!
FoRM providers kicked back this week for our month FoRM providers kicked back this week for our monthly book club 📚—this month’s pick: The Blacktongue Thief by Christopher Buehlman. We gathered at @oranmormead in Sellwood, a new local spot, to swap insights (and laughs) over mead. 🍯✨

We love supporting local businesses while building community with our team.

#FoRMHealth #BookClub #sellwoodmoreland 
@sblaney22 @drcaitlanreadhead @constant_balance_acupuncture @colburn.natasha
Reclaim your health routine! Sleep, Stress, Move + Reclaim your health routine! Sleep, Stress, Move + Eat better with services @formhealthpdx.com
#naturopathicmedicine #functionalmedicine #hormonehealth #functionalnutrition #acupuncture #chiropracticcare #sleepbetter

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