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Botox®  vs. Xeomin®: Choosing the Right Neurotoxin to Combat Wrinkles

By FoRM Health | January 29, 2025

At FoRM Health in Portland, Oregon, we specialize in helping you look and feel your best—which may include rewinding back the clock on wrinkles using neurotoxin injections. If you’re considering injections to smooth those unwanted signs of aging, you’ve likely come across two popular options: Botox® and Xeomin®. While both yield wonderful results, they have some key differences that may influence which one is right for you. Let’s break it down.

What Do Botox™ and Xeomin™ Have in Common?

Both Botox® and Xeomin® are FDA-approved neurotoxins (derived from botulinum toxin) for the treatment of wrinkles of the forehead, frown lines (also known as “11” lines), and crow’s feet around the eyes. They work by temporarily relaxing the muscles that cause the dynamic wrinkle (wrinkle caused by movement). The result? Smoother, more youthful-looking skin. Both treatments are quick, minimally invasive, and require no downtime.

3 Key Differences Between Botox® and Xeomin®

Purity of Formulation

    • Botox®: Botox contains additional accessory proteins alongside the active ingredient, botulinum toxin. While these proteins are generally considered innocuous, they theoretically could trigger an immune response resulting in antibody formation against the proteins, potentially reducing its effectiveness over time.
    • Xeomin®: Known as a “naked” neurotoxin, Xeomin® is free of added proteins, containing only the active ingredient. This pure formulation may reduce the risk of developing antibody resistance, making it a great choice for long-term use.

 

Stronger vs. Lighter Effect:

    • Botox®: With the additional proteins, Botox® has a greater molecular weight than Xeomin®, resulting in Botox™ having a more precise and “heavier” effect in the treated area. This feature makes it the better option for individuals with strong facial expressions or those seeking minimal to no facial movement within the treated area. 
    • Xeomin®: Without the accessory proteins, Xeomin™ has a more diffuse distribution within the treated area, resulting in a “lighter” land. This “lighter” effect is thought to create a more “natural” look, allowing for some muscle movement while turning down the wrinkle formation.

 

Onset + Duration of Results:

    • Botox®: With a slightly stronger effect, results are typically first noticed 3-5 days after treatment, though the full effect may take up to 2 weeks to settle in. On average, the results from one Botox® treatment lasts about 3 months.
    • Xeomin®: The lighter quality of Xeomin® may take a few more days to settle in, typically showing up 5-7 days after treatment, with the full expression of results showing up at 2 weeks, just like Botox®. Xeomin®, however, has been reported to last longer for some patients, averaging 3.5 month duration of results. The difference in duration of effect may be attributed to the accessory proteins.

Which One Is Right for You?

The best neurotoxin for you depends on your individual needs, lifestyle, and goals. Some patients prefer Xeomin® for its pure formulation and more natural aesthetic, while others stick with Botox® for its consistent and sometimes stronger results. During your consultation at FoRM Health, Dr. Kai will discuss your aesthetic goals and help you choose the option that’s best suited for you!

Why Choose FoRM Health for Your Neurotoxin Treatments?

At FoRM Health, we combine aesthetic expertise with a holistic approach to wellness. Our goal is not just to reduce wrinkles but to enhance your natural beauty and skin health. Whether you’re new to neurotoxin treatments or looking to switch things up, you can trust us to deliver personalized care with a natural aesthetic.

Ready to smooth away wrinkles and embrace a more youthful look? Schedule your consultation at FoRM Health in Portland today!

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Your skin. Every month. Better than the last. ✨

Our Age Defy Membership — clinically advanced, results-driven aesthetics designed to compound month over month. 

Always natural. Always you — just refreshed.
─
Age Defy Gold · 90 min · $649/mo 

PRF Bio-Filler naturally restores lost volume in the under-eyes, cheeks and folds — no synthetic filler. Combined with full-face Microneedling with PRF and Red Light Therapy, the results are real, progressive and unmistakably you.

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Age Defy Silver · 75 min · $549/mo 

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─
All members receive: → 
Botox® & Xeomin® at $11/unit → 
10% off aesthetic services + skincare → 
Priority scheduling

3-month minimum. Billed monthly.
Which tier is right for you? 👉 Book a complimentary consultation — link in bio.

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A layered, device-forward experience that combines the best of skincare technology — hydrodermabrasion, microcurrent, ultrasonic exfoliation, and more — with expert therapeutic bodywork including craniosacral therapy +  facial sculpting massage. 

Finished with clinical-grade skincare from SkinBetter Science, Circadia, and Epionce.
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Need more guidance on recovery & moving pain free? We got you! Link in bio to schedule. 🔗 

#formhealth #movebetter #orthopedic #naturopathicmedicine #regenerativemedicine #feelbetter #recoverytools #dryneedle #sportsrehabilitation
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🌿 Prolozone — Ozone-based therapy that reduces oxidative stress and delivers targeted support to healing tissue
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You deserve more than symptom management. You deserve a path back. 💪 

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Your Body is Designed to Heal. Regenerative Inject Your Body is Designed to Heal. Regenerative Injection Therapy Harnesses That Power. 
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What if you didn’t have to be limited by pain or o What if you didn’t have to be limited by pain or old injuries? 🏋🏽‍♂️

Regenerative injection therapies (RIT) use your body’s natural healing abilities to reduce inflammation, repair tissues, and relieve pain—helping you move better without surgery or relying on medications.

✨ RIT Therapies at FoRM:

✅ Prolotherapy – A simple sugar solution, that strengthens weakened + damaged connective tissue (ligaments/sprains)
✅ Platelet Rich Plasma – Concentrated platelet solution, harnessed from your own blood, which uses growth factors to repair injuries (tendons/muscle tears and strains)
✅ MFAT Therapy – Fat-derived regenerative cells that provide a powerful healing signal for old injuries and damaged joints (arthritis, cartilage damage)

FoRM is Portland’s trusted resource for non-surgical, regenerative solutions for pain + injuries. 

Want to learn if you’re a good fit for RIT? Schedule a Consult one of our specialists - Dr. Ryan Minarik ND and Dr. Brittany Krake ND - by calling 503 232 5653 opt 2 or using scheduling link in bio.

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We have 4 physicians at FoRM who specialize in hor We have 4 physicians at FoRM who specialize in hormones + women’s health. They’re here to support you in navigating perimenopause & menopause with style and grace! Dr. Herman, Dr. Krake, + Dr. Binshaieg share their go to supplementation to help our patients navigate this phase of life! 

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🌷Vitex
🌷Rhapontic Rhubarb
🌷Creatine
🌷Collagen

There are so many wonderful botanicals that we can lean on to keep us feeling + moving better. #formhealthpdx 

Link in bio to schedule! 

#hormonehealth #hormonebalance #womenshealth #menopause #perimenopause #feelbetter #movebetter #botanical #naturopathicphysician

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