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Botox®  vs. Xeomin®: Choosing the Right Neurotoxin to Combat Wrinkles

By FoRM Health | January 29, 2025

At FoRM Health in Portland, Oregon, we specialize in helping you look and feel your best—which may include rewinding back the clock on wrinkles using neurotoxin injections. If you’re considering injections to smooth those unwanted signs of aging, you’ve likely come across two popular options: Botox® and Xeomin®. While both yield wonderful results, they have some key differences that may influence which one is right for you. Let’s break it down.

What Do Botox™ and Xeomin™ Have in Common?

Both Botox® and Xeomin® are FDA-approved neurotoxins (derived from botulinum toxin) for the treatment of wrinkles of the forehead, frown lines (also known as “11” lines), and crow’s feet around the eyes. They work by temporarily relaxing the muscles that cause the dynamic wrinkle (wrinkle caused by movement). The result? Smoother, more youthful-looking skin. Both treatments are quick, minimally invasive, and require no downtime.

3 Key Differences Between Botox® and Xeomin®

Purity of Formulation

    • Botox®: Botox contains additional accessory proteins alongside the active ingredient, botulinum toxin. While these proteins are generally considered innocuous, they theoretically could trigger an immune response resulting in antibody formation against the proteins, potentially reducing its effectiveness over time.
    • Xeomin®: Known as a “naked” neurotoxin, Xeomin® is free of added proteins, containing only the active ingredient. This pure formulation may reduce the risk of developing antibody resistance, making it a great choice for long-term use.

 

Stronger vs. Lighter Effect:

    • Botox®: With the additional proteins, Botox® has a greater molecular weight than Xeomin®, resulting in Botox™ having a more precise and “heavier” effect in the treated area. This feature makes it the better option for individuals with strong facial expressions or those seeking minimal to no facial movement within the treated area. 
    • Xeomin®: Without the accessory proteins, Xeomin™ has a more diffuse distribution within the treated area, resulting in a “lighter” land. This “lighter” effect is thought to create a more “natural” look, allowing for some muscle movement while turning down the wrinkle formation.

 

Onset + Duration of Results:

    • Botox®: With a slightly stronger effect, results are typically first noticed 3-5 days after treatment, though the full effect may take up to 2 weeks to settle in. On average, the results from one Botox® treatment lasts about 3 months.
    • Xeomin®: The lighter quality of Xeomin® may take a few more days to settle in, typically showing up 5-7 days after treatment, with the full expression of results showing up at 2 weeks, just like Botox®. Xeomin®, however, has been reported to last longer for some patients, averaging 3.5 month duration of results. The difference in duration of effect may be attributed to the accessory proteins.

Which One Is Right for You?

The best neurotoxin for you depends on your individual needs, lifestyle, and goals. Some patients prefer Xeomin® for its pure formulation and more natural aesthetic, while others stick with Botox® for its consistent and sometimes stronger results. During your consultation at FoRM Health, Dr. Kai will discuss your aesthetic goals and help you choose the option that’s best suited for you!

Why Choose FoRM Health for Your Neurotoxin Treatments?

At FoRM Health, we combine aesthetic expertise with a holistic approach to wellness. Our goal is not just to reduce wrinkles but to enhance your natural beauty and skin health. Whether you’re new to neurotoxin treatments or looking to switch things up, you can trust us to deliver personalized care with a natural aesthetic.

Ready to smooth away wrinkles and embrace a more youthful look? Schedule your consultation at FoRM Health in Portland today!

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Most healthcare treats symptoms one at a time. We Most healthcare treats symptoms one at a time.
We do it differently.

At FoRM, our NDs and acupuncturists work as a team — using your symptoms as clues to the systems that actually need support.
Hormones. Stress + sleep. Allergies + immunity. Chronic digestion.
Four areas where two lenses are better than one. 

If this strategy resonates with you, schedule with a FoRM provider using link in bio!

#functionalmedicine #naturopathicmedicine #acupuncture #hormonehealth #feelbetter
Watch our skin health & glow experts, Dr. Kai + O’ Watch our skin health & glow experts, Dr. Kai + O’Brien rate advanced aesthetic treatments! They cover a variety of popular professional aesthetic services & their hot takes:

✨Chemical Peels
✨Laser Skin Tightening 
✨IPL or Intense Pulsed Light
✨Fillers 
✨PDO Threads 
✨Botox/Xeomin
✨PRF or Platelet Rich Fibrin Facials 
✨MicroNeedling 

Watch to the end to hear about which treatments get TEN STARS when paired together! 👀 👀 

⭐️⭐️⭐️⭐️⭐️⭐️⭐️⭐️⭐️

#glowup #skinhealth #shinefromwithin #plateletrichfibrin #botox #naturalaesthetics #lookbetter #skingoals #skinglow
What can Age Defy deliver? Your skin. Every month What can Age Defy deliver?

Your skin. Every month. Better than the last. ✨

Our Age Defy Membership — clinically advanced, results-driven aesthetics designed to compound month over month. 

Always natural. Always you — just refreshed.
─
Age Defy Gold · 90 min · $649/mo 

PRF Bio-Filler naturally restores lost volume in the under-eyes, cheeks and folds — no synthetic filler. Combined with full-face Microneedling with PRF and Red Light Therapy, the results are real, progressive and unmistakably you.

✦ Natural volume + lift 
✦ Smoother, firmer skin 
✦ Even + brighter complexion
─

Age Defy Silver · 75 min · $549/mo 

Microneedling with PRF harnesses your skin’s own healing power to rebuild from within — fading pigmentation, smoothing texture and restoring that lit-from-within hydration, naturally.

✦ Softer fine lines + smoother texture 
✦ Fades discoloration + brightens tone 
✦ Dewy, firmer complexion over time
─

Age Defy Bronze · 60 min · $329/mo 

Microneedling triggers your skin’s natural collagen response — gently resurfacing and reviving from within. Red Light Therapy amplifies the results for skin that’s calmer, clearer and genuinely glowing.

✦ Smoother texture
✦ Clearer complexion 
✦ A healthy, natural glow that builds over time
─
All members receive: → 
Botox® & Xeomin® at $11/unit → 
10% off aesthetic services + skincare → 
Priority scheduling

3-month minimum. Billed monthly.
Which tier is right for you? 👉 Book a complimentary consultation — link in bio.

#formhealth #lookbetterfeelbetter #skingoals #regenerativeaesthetics #microneedling
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A layered, device-forward experience that combines the best of skincare technology — hydrodermabrasion, microcurrent, ultrasonic exfoliation, and more — with expert therapeutic bodywork including craniosacral therapy +  facial sculpting massage. 

Finished with clinical-grade skincare from SkinBetter Science, Circadia, and Epionce.
A custom skin care experience that provides exactly what your skin +nervous system need in the moment. 
The kind of treatment that leaves you glowing from the inside out.

And now? You can make it a ritual with our packages:

Golden Hour Facial (60 min) → 3-pack: $600 ($200/session) → 6-pack: $900 ($150/session)
Golden Hour Plus Facial (90 min) → 3-pack: $810 ($270/session) → 6-pack: $1,500 ($250/session)

Build your glow. Link in bio to book

#agedefy #lookbetterfeelbetter #formhealthpdx #formhealthaesthetics #goldenhour
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💅🏻 Wrinkle Patches 
💅🏻 Exfoliation

If you’d like to go deeper & find out what type of care YOUR skin wants + needs — click our link in bio to schedule a complimentary consultation with O’Brien. We’ve got so many tools & ideas for you! ⭐️⭐️⭐️⭐️⭐️ 

#skincareroutine #shinefromtheinsideout #beautytrends #agestrong #skinhealth #functionalaesthetics #naturalskincare
What makes Age Defy Membership different? Occasion What makes Age Defy Membership different?
Occasional treatments get you occasional results.
Real skin transformation? That takes consistency.
Age Defy Memberships are built for exactly that — monthly regenerative treatments that compound over time. Collagen rebuilds. Volume restores. Tone, texture, and radiance improve month after month, in ways a single session simply can’t replicate.

This isn’t aesthetics that changes you. It’s aesthetics that works with you.
Healthy. Glowing. Vibrantly yourself. 🤍

Age Defy Membership Tiers:
✦ GOLD — 90 min · $649/mo PRF Bio-Filler + Microneedling with PRF + Red Light Therapy Volume. 
Restore. Plump. Lift => Full-face Renewal — month after month.
✦ SILVER — 75 min · $549/mo Microneedling with PRF + Red Light Therapy
Even. Smooth. Firm => Full face Refresh - month after month.
✦ BRONZE — 60 min · $329/mo Microneedling + Red Light Therapy 
Brighten. Hydrate. Glow => Full face Radiance — month after month.

Every Age Defy Member also gets: → Botox® & Xeomin® at $11/unit (typically $14/unit)→ 10% off facials, laser + skincare → Priority scheduling
Which tier is yours? 🤍 #AgeDefy #formhealth SkinGoals #PRFFacial #GlowUp
We rebuilt our aesthetics program around what you We rebuilt our aesthetics program around what you love most. 🌟

When you look good, you feel good — and when you feel good, you make choices that reinforce both. Healthier habits, better sleep, more intentional self-care. It all compounds. That's why our approach to aesthetics is rooted in health first, using treatments that harness your natural biology and designed to bring out the best you - so you're inspired to lead a lifestyle that amplifies your vibrance from the inside out.

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🤸‍♀️ Theragun
🤸‍♀️ Hydration
🤸‍♀️ Lacrosse Balls
🤸‍♀️ Restorative Yoga
🤸‍♀️ Foot Soaks
🤸‍♀️ Red Light Therapy 
🤸‍♀️ Sauna
🤸‍♀️ Stretching 

Need more guidance on recovery & moving pain free? We got you! Link in bio to schedule. 🔗 

#formhealth #movebetter #orthopedic #naturopathicmedicine #regenerativemedicine #feelbetter #recoverytools #dryneedle #sportsrehabilitation
Even the most dedicated providers need a recharge Even the most dedicated providers need a recharge — and for the FoRM crew, nothing beats getting lost in a great book!

This month, FoRM’s Book Club took over Oma’s Hideaway to swap thoughts on Wild Dark Shore over delicious food, drinks and even better company. We came for the book. We stayed for the vibes. 🌿🕯️

#FoRMBookClub #WildDarkShore #OmasHideaway #ReadMoreBooks #formhealthpdx
At FoRM we believe pain treatments should come wit At FoRM we believe pain treatments should come with a plan — not just a prescription! 💡 

That’s why we offer a suite of targeted therapies that are highly effective as standalone therapies but can also be used in conjunction with regenerative injection therapies to optimize outcomes:

🎯 Trigger Point Injections — Addresses muscular dysfunction that loads and stresses the very joints and tissues being regenerated.

⚡ Shockwave Therapy — Stimulates tissue repair and increases local circulation to enhance the regenerative environment

🧠 Nerve Hydrodissection — Ultrasound-guided release of compressed nerves that may be undermining your recovery without you knowing it.

🌿 Prolozone — Ozone-based therapy that reduces oxidative stress and delivers targeted support to healing tissue
Whether you’re just beginning your healing journey or already undergoing Prolotherapy, PRP, or MFAT — these therapies meet you where you are, and help carry you further than you thought possible.

You deserve more than symptom management. You deserve a path back. 💪 

#FoRMHealth #RegenerativeMedicine #Prolotherapy #PRP #MFAT #ShockwaveTherapy #Prolozone #NeuralTherapy #Hydrodissection #IntegrativeOrthopedics #ChronicPainRelief #FunctionalMedicine #WholeBodyHealing #PortlandOR
Your Body is Designed to Heal. Regenerative Inject Your Body is Designed to Heal. Regenerative Injection Therapy Harnesses That Power. 
#movebetter #movebetterfeelbetter #formhealth #nonsurgicalsolutions

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